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[PMC free article: PMC10984693] [PubMed: 38562158] (48 year old man with severe alcohol use disorder started taking TestBoost [containing 8 ingredients including ashwagandha, long jack, eleuthero, ginseng, mushroom extract, bindi and horny goat weed] for alcohol withdrawal symptoms and developed jaundice 3 days later [bilirubin 13.6 mg/dL, ALT 49 U/L, AST 58 U/L Alk P 98 U/L, INR 1.1], with slow recovery and relapse in alcohol use in follow up)

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EDC/NHS chemistry was used to graft functional groups (alanine and GSH), couple therapeutic molecules (ibuprofen and dopamine) on PLG backbone and label the co-polypeptides with R6G (Fig